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Article: Effect of neonatal asphyxia on the impairment of the auditory pathway by recording auditory brainstem responses in newborn piglets: a new experimentation model to study the perinatal hypoxic-ischemic damage on the auditory system.

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Alvarez FJ; Revuelta M; Santaolalla F; Alvarez A; Lafuente H; Arteaga O; Alonso-Alconada D; Sanchez-del-Rey A; Hilario E; Martinez-Ibargüen A
PLoS ONE, 2015


10.1371/journal.pone.0126885.t001 Neurophysiological assessment of piglets: amplitude-integrated electroencephalography aEEG, tissue oxygenation index (TOI) and normalized tissue hemoglobin index (nTHI) in control and Hypoxic-Ischemic (HI) groups.
Neurophysiological assessment (mean±SD) Basal 20 minutes 1 hour 3 hours 6 hours
aEEG Control (μV) 21,00 ± 1,10 22,00 ± 1,10 21,00 ± 0,57 22,00 ± 1,23 23,00 ± 1,19
aEEG HI (μV) 23,50 ± 1,32 1,92 ± 0,55 2,33 ± 0,57 2,72 ± 0,81 3,12 ± 0,77
TOI Control (%) 50,00 ± 0,66 51,67 ± 0,66 52,33 ± 0,95 52,33 ± 1,06 52,67 ± 0,49
TOI HI (%) 52,00 ± 1,12 26,63 ± 1,12 50,25 ± 1,42 52,00 ± 0,48 53,29 ± 0.69
nTHI Control (%) 95,67 ± 2,94 96,33 ± 3,00 95,00 ± 4,29 93,33 ± 3,53 93,00 ± 5,35
nTHI HI (%) 99,13 ± 2,75 122,80 ± 3,93 107,63 ± 2,70 110,00 ± 3,76 104,57 ± 2,24

HI: Hypoxia-ischemia. TOI: tissue oxygenation index. nTHI: normalized tissue hemoglobin index. SD: standard deviation


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